Carnosine Supplement:
How Could We Have Overlooked YOU?!

To add a carnosine supplement is not a habit that many people are accustomed to.

Most of us have heard more about antioxidants such as vitamins C, A, and E, alphalipoic acid, and CoQ10.

However, carnosine is an important nutrient for the protection against the damages of aging from glycation and carbonylation.

Wait. Car-know-what??

Carnosine is a dipeptide, which is a molecle consisting of two amino acids, histidine and beta-alanine. It is highly concentrated in brain, muscle tissue, and nerve cells.

Glycation refers to the process where glucose binds to protein molecules, and carbonylation occurs when a carbonyl molecule attaches to protein. Both of these processes alter the protein, and it's never to your advantage or benefit.
Protein glycation and carbonylation also occur to your skin cells, and this is one of the main intrinsic reasons why the skin ages.

Glycation

Glycation occurs via two methods:
From Our Diet/Exogenous
Exogenous glycation and Advanced Glycation Endproducts (AGEs) occur during the food cooking process when sugars are cooked with fats or proteins. Both exogenous glycation and AGEs are proving to be significant contributors to inflammation and diseases such as cardiovascular disease, Alzheimer's, peripheral neuropathy and even deafness. Unfortunately, more food manufactures have added AGEs as a flavor enhancer and to improve food color.

From Inside Our Bodies/Endogenous
This is a consequence of the food we ingest. You probably have heard of warnings to reduce the amount of high fructose corn syrup in our diets. That's because fructose has 10 times the glycation activity of glucose.

Carbonylation

If protein cells become heavily carbonylated, through oxidative stress/free radicals, they form high-molecular weight aggregates which accumulate as damaged proteins. A large amount of these aggregated proteins can produce irreversible damage leading to Parkinson's, Alzheimer's, and other neurodegenerative diseases.

Research is showing carnosine supplement to be a promising broad-spectrum shield that is effective against nearly all of the chemical processes that destroy protein and make us age. Our natural carnosine levels steadily decline as we age.

So how else might CARNOSINE be important to us?? Glad you asked, read on!

Hayflick Limit: Theory of Aging

One theory of aging involves what's known as the Hayflick Limit.
This phenomenon, discovered by Leonard Hayflick in 1961, theorizes that a human cell can divide and replicate about 40 to 60 times before it dies.

The number of replications is determined by the telomere region found at the end of a DNA strand in cells. It's a bit of a catch 22 because the telomeres allow the cell to replicate, but each time a strand of DNA divides a piece of the telomere is lost and is shortened.

Eventually, the telomeres become depleted and the cell dies (also called apoptosis).

A carnosine supplement can increase the Hayflick limit in human fibroblasts, the same cells which produce collagen and elastin! Collagen is also found in the walls of our blood vessels. If blood vessels have less collagen they become more stiff, leading to high blood pressure, and can weaken leading to micro/macroaneurism and strokes.



Ah, now it's making a bit more sense!

So where can you find carnosine supplement or sources?
The main dietary source is red meat, but for those trying to maintain a MAP diet (Minimal Animal Protein) we may be consuming lower amounts of red meat.

Sources & Dosaging

Food sources: milk, eggs, cheese, beef, poultry, and pork. The enzyme which breaks down carnosine is so efficient that you would have to eat a 7 oz steak, three times a day to get sufficient carnosine levels!

It is highly recommended that all vegetarians use a carnosine supplement.

So if we are consuming less meat, carnosine supplementation may be advised. You should take at least 1000mg per day, all at once. If you take less, an enzyme will digest your carnosine supplement as you take it, and it will do you little good. The trick is to take more than the enzyme can break down so the remaining carnosine can serve as the active component in your body.

In a multivitamin, carnosine is present in quantities of only 50mg to 100mg. Hardly enough to do anything! The only way to get sufficient quantities of carnosine is to take a separate supplement.

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